R 24571
1-[bis(4-chlorophenyl)methyl]-3-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazol-3-ium chloride
CAS: 57265-65-3
Molecular Formula: C31H23Cl7N2O
R 24571 - Names and Identifiers
| Name | 1-[bis(4-chlorophenyl)methyl]-3-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazol-3-ium chloride |
| Synonyms | R 24571 CALMIDAZOLIUM COMPOUND R24571 R 24571 CHLORIDE CALMIDAZOLIUM CHLORIDE CALMODULIN INHIBITOR R 24571 3-[Bis(4-chlorophenyl)methyl]-1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazol-3-ium chloride 1-[bis(4-chlorophenyl)methyl]-3-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazol-3-ium chloride 1-[Bis(4-chlorophenyl)methyl]-3-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazol-3-ium chloride |
| CAS | 57265-65-3 |
| InChI | InChI=1/C31H23Cl6N2O.ClH/c32-23-6-1-20(2-7-23)31(21-3-8-24(33)9-4-21)39-14-13-38(19-39)17-30(27-12-11-26(35)16-29(27)37)40-18-22-5-10-25(34)15-28(22)36;/h1-16,19,30-31H,17-18H2;1H/q+1;/p-1 |
R 24571 - Physico-chemical Properties
| Molecular Formula | C31H23Cl7N2O |
| Molar Mass | 687.7 |
| Melting Point | 172-176 °C |
| Water Solubility | Soluble in dimethyl sulfoxide, ethanol. methanol, chloroform, and propylene glycol. Insoluble in water. |
| Appearance | solid |
| Color | white |
| BRN | 6470244 |
| Storage Condition | 2-8°C |
R 24571 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 2811 6.1 / PGII |
| WGK Germany | 3 |
| RTECS | Gk2402500 |
| FLUKA BRAND F CODES | 3-8-10 |
| HS Code | 29332990 |
R 24571 - Reference Information
| Biological activity | Calmidazolium chloride (R 24571) is a calmodulin antagonist that antagonizes CaM-dependent phosphodiesterase and calmodulin-induced erythrocyte Ca2 + transport ATPase activation, IC50 is 0.15 and 0.35 μM respectively. It is also used in anti-cancer research. It binds CaMK with a Kd value of 3 nM. |
| target | Kd: 3 nM (Calmodulin) |
| Cell Line: | Mouse F9 ECCs |
| Concentration: | 3, 5, 7, 10 μM |
| Incubation Time: | 30 minutes-24 hours |
| Result: | The IC 50 s of Calmidazolium chloride treated F9 ECCs and E14 ESCs are 8.18 μM, and 12.69 μM [2] . |
Last Update：2024-04-10 22:29:15
